Resistance in a non-linear autoregressive model of pulmonary mechanics

Resistance in a non-linear autoregressive model of pulmonary mechanics

Blog Article

Respiratory system modelling can enable patient-specific mechanical ventilator settings to be found, and can thus reduce the incidence of ventilator induced lung injury in the intensive care unit.The Splints resistance of a simple first order model (FOM) of pulmonary mechanics was compared with a flow dependent term of a non-linear autoregressive (NARX) model.Model parameters were identified for consecutive non-overlapping windows of length 20 breaths.

The analysis was performed over recruitment manoeuvres for 25 sedated mechanically ventilated patients.The NARX model term, b1, consistently decreased as positive Bike Parts - Spokes end expiratory pressure (PEEP) increased, while the FOM resistance behaviour varied.Overall the NARX b1 behaviour is more in-line with expected trends in airway resistance as PEEP increases.

This work has further verified the physiologically descriptive capability of the NARX model.